Yazarlar : Dimou M, Angelopoulou M, Pangalis G

Yayın : Leuk Lymphoma.

Yayın Yılı : 2012

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/22280533

Konu : Anemi

Literatür İçeriği :  

Abstract

Abstract Autoimmune hemolytic anemia and thrombocytopenia (AIHA/AITP) frequently complicate the course of non-Hodgkin's lymphomas, especially low-grade, but they are very rarely observed in Hodgkin lymphoma (HL). Consequently the frequency and the profile of patients with HL-associated AIHA/AITP have not been well defined. Among 1029 HL patients diagnosed between 1990 and 2010, 2 cases of AIHA (0.19%) and 3 of AITP (0.29%) were identified at presentation of the disease. These patients were significantly older, had more frequently features of advanced disease and non-nodular sclerosing histology, compared to the majority of patients, who did not have autoimmune cytopenias at diagnosis. ABVD combination chemotherapy provided effective control of HL and the autoimmune condition as well. During approximately 6600 person-years of follow-up for the remaining 1024 patients, 7 (0.7%) patients developed autoimmune cytopenias (3 AITP, 3 AIHA, 1 autoimmune pancytopenia) for a 10- and 15-year actuarial incidence of 0.95% and 1.40% respectively. Their features did not differ compared to the general population of adult HL. In this large series of consecutive, unselected patients, those who presented with autoimmune cytopenias had a particular demographic and disease-related profile. In contrast, patients developing autoimmune cytopenias during follow-up did not appear to differ significantly from those who did not.

Literatür Arşivi