Yazarlar : Hovland A, Marcovina S, Hardersen R, Enebakk T, Mollnes TE, Lappegård KT.

Yayın : Transfus Apher Sci.

Yayın Yılı : 2011

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/22206792

Konu : Aferez

Literatür İçeriği :  

Abstract

INTRODUCTION:

High levels of lipoprotein(a) [Lp(a)] and apolipoprotein(a) [apo(a)] are associated with cardiovascular disease. In this study we determined apo(a) particle size and compared the Lp(a) reducing efficacy of three different LDL apheresis columns; DL-75, LA-15 and EC-50W in patients with familial hypercholesterolemia (FH).

RESULTS:

Average Lp(a) concentration was reduced by 70%, 74% and 75% (all p<0.0001) for DL-75, LA-15 and EC-50W, respectively. No significant changes in the relative proportion of the isoforms of 14 and 32K 4 domains were observed after apheresis.

CONCLUSION:

Three different LDL apheresis columns reduced Lp(a) efficiently with preserved ratio between apo(a) isoforms.

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