Yazarlar : Styczynski J, Balduzzi A, Gil L, Labopin M, Hamladji RM, Marktel S, Yesilipek MA, Fagioli F, Ehlert K, Matulova M, Dalle JH, Wachowiak J, Miano M, Messina C, Diaz MA, Vermylen C, Eyrich M, Badell I, Dreger P, Gozdzik J, Hutt D, Rascon J, Dini G, Peters C.

Yayın : Blood.

Yayın Yılı : 2011

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/22160619

Konu : Aferez

Literatür İçeriği :  

Abstract

We prospectively investigated factors influencing the safety of hematopoietic stem cell (HSC) collection in 453 pediatric donors. The children in the study donated either bone marrow (BM) or peripheral blood stem cells (PBSC), according to center policy. A large variability in approach to donor issues was observed between the participating centers. Significant differences were observed between BM and PBSC donors regarding pain, bloodallotransfusion, duration of hospital stay and iron supplementation, although differences between the groups undergoing BM vs PBSC donation preclude direct risk comparisons of the two procedures. The most common adverse event was pain, reported mainly by older children after BM harvest, but also observed after central venous catheter (CVC) placement for PBSC collection. With regard to severe adverse events, one patient (0.7%) developed a pneumothorax with hydrothorax after CVC placement for PBSC collection. The risk of allotransfusion after BM harvest was associated with a donor age of <4 years and a BM harvest volume of >20 mL/kg. We conclude that PBSC and BM collections are safe procedures in children. Children <4 years were at higher risk than older children for allotransfusion following BM harvest, and a higher risk of complications from CVC placement prior to apheresis.

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