Yazarlar : Evens AM, Helenowski I, Ramsdale E, Nabhan C, Karmali R, Hanson B, Parsons B, Smith S, Larsen A, McKoy JM, Jovanovic B, Gregory S, Gordon LI, Smith SM.

Yayın : Blood

Yayın Yılı : 2011

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/22117038

Konu : Geriyatrik Hematoloji

Literatür İçeriği :

Abstract

We investigated a recent (1/99-12/09) cohort of 95 elderly Hodgkin lymphoma subjects. At diagnosis, median age was 67 years (60-89), while 61% had significant co-morbidity, 17% had a geriatric syndrome, 26% were unfit, and 13% had loss of activities of daily living (ADL). Response rate to therapy was 85%, while incidence of bleomycin lung toxicity was 32% (associated mortality rate: 25%). With 66-month median follow-up, 2-year and 5-year overall survival (OS) were 73% and 58%, respectively (advanced-stage: 63% and 46%, respectively). Most IPS factors were not prognostic on univariate analyses, while multivariate regression identified 2 risk factors associated with inferior OS: 1) Age >70 years (2.24 (95%CI 1.16-4.33), p=0.02) and 2) Loss of ADLs (2.71 (95%CI 1.07-6.84), p=0.04). Furthermore, a novel survival model based on number of risk factors (0, 1, or 2) showed differential 2-year OS 83%, 70%, 13%, respectively (p<0.0001), and 5-year OS 73%, 51%, 0%, respectively (p<0.0001).

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