Literatür Detay Bilgisi
Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma.
Yazarlar : Mansour MR, Look AT.
Yayın : Cancer Cell.
Yayın Yılı : 2011
Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/22094251
Konu : Lenfoma
Literatür İçeriği :
Abstract
In a recent paper in Cell, Oricchio et al. identify EPHA7 as a tumor suppressor gene residing in the 6q-deleted region in follicular lymphoma. A truncated EPHA7(TR) isoform is secreted by normal B cells, inhibits EPHA2 signaling, and, as a secreted tumor suppressor protein, has potential as a targeted therapeutic polypeptide
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