Yazarlar : Abbas W, Ismail N, Hassanein SM.

Yayın : J Matern Fetal Neonatal Med.

Yayın Yılı : 2011

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/21919551

Konu : Transfüzyon

Literatür İçeriği :  

Abstract

Abstract Objective: Evaluation of two-stage single- volume exchange transfusion (TSSV-ET) in decreasing the post-exchange rebound increase in serum bilirubin level, with subsequent reduction of the need for repeated exchange transfusions. Methods: The study included 104 neonates with hyperbilirubinemia needing exchange transfusion. They were randomly enrolled into two equal groups, each group comprised 52 neonates. TSSV-ET was performed for the 52 neonates and the traditional single-stage double-volume exchange transfusion (SSDV-ET) was performed to 52 neonates. Results: TSSV-ET significantly lowered rebound serum bilirubin level (12.7±1.1 mg/dL), compared to SSDV-ET (17.3±1;1.7 mg/dL), P<0.001. Need for repeated exchange transfusions was significantly lower in TSSV-ET group (13.5%), compared to 32.7% in SSDV-ET group, P<0.05. No significant difference was found between the two groups as regards the morbidity (11.5% & 9.6% respectively) and the mortality (1.9% for both groups). Conclusion: Two-stage single volume exchange transfusion proved to be more effective in reducing rebound serum bilirubin level post-exchange and in decreasing the need for repeated exchange transfusions.

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