Yazarlar : Mali P, Cheng L.

Yayın : Stem Cells.

Yayın Yılı : 2011

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/21905170

Konu : Rejeneratif Tıp

Literatür İçeriği :  

Abstract

Cell engineering is defined here as the collective ability to both reset and edit the genome of a mammalian cell. Until recently this had been extremely challenging to achieve in human cells, because non-transformed human cells are significantly refractory to both these processes. The recent success in reprogramming somatic cells into induced pluripotent stem cells that are self-renewable in culture, coupled with our increasing ability to effect precise and pre-designed genomic editing, now readily permits cellular changes at both the genetic and epigenetic levels. These dual capabilities thus also make possible the generation of genetically-matched, disease-free stem cells from patients for regenerative medicine. The objective of this review is to summarize the key enabling developments on these two rapidly evolving research fronts in human cell engineering, highlight unresolved issues, and outline potential future research directions.

Literatür Arşivi

Sunumlar	Videolar	Olgu Tartışması
Incorporating Molecular Data into Risk Stratification for AML	Neden Hematolojiyi seçtim?	Abstract Introduction: Aplastic anemia is a rare disease caused by destruction of pluripotent stem cells in bone marrow. During pregnancy it could be life-threatening for both mother and child. The only causal therapy for aplastic anemia is bone marrow t Novel therapies delay the progression of smoldering multiple myeloma: