Yazarlar : Benhardt H, Sears N, Touchet T, Cosgriff-Hernandez E.

Yayın : Macromol Biosci.

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/21681959

Konu : Rejeneratif Tıp

Literatür İçeriği :  

Abstract

Recently, poly(ester urethanes) were investigated for use as ligament grafts due to their exceptional mechanical properties and highly tunable structure; however, these grafts are susceptible to hydrolytic degradation that occurs independent of tissue regeneration. To address this limitation, polyureas containing collagen-derived peptides were synthesized which enable cellular release of proteases to dictate degradation rate. It is hypothesized that this cell-responsive design will facilitate load transfer from the biodegradable scaffold to neotissue at a rate that promotes proper tissue orientation and function while maintaining construct integrity.

Literatür Arşivi

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