Literatür Detay Bilgisi
Antithrombotic Activity of a New Benzimidazole Derivative in the Thrombosis Model in Mice

Yazarlar : Smirnov AV, Kucheryavenko AF, Spasov AA et al

Yayın : Bull Exp Biol Med.

Yayın Yılı : 2014

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/25257418

Konu : Tromboz

Literatür İçeriği :  

Abstract

Antithrombotic activity of a new benzimidazole derivative RU-891, characterized by antiaggregant activity, vs. reference drug acetylsalicylic acid was studied on the epinephrinecollagen thrombosis model in mice. Antithrombotic activity of RU-891 3-fold surpassed that of the reference drug. Histological studies showed that RU-891 significantly reduced the relative and mean areas of thrombi in sections of mouse lungs in comparison with the control.


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