| Literatürler Hematoloji Uzmanlık Derneği
Literatür Detay Bilgisi
Ulcerative colitis and granulocyte-monocyte-apheresis: Safety and efficacy of maintenance therapy during pregnancy.

Yazarlar : D'Ovidio V, Meo D, Gozer M et al

Yayın : J Clin Apher

Yayın Yılı : 2014

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/25181523

Konu : Aferez

Literatür İçeriği :  

Abstract

Inflammatory bowel disease characteristically affects young adults in their reproductive ages. Thus the medication used for the treatment of active disease should not compromise fertility and, also, should not have teratogenic effect on baby. A lot of data are available about effects of steroids, antibiotics, and mesalazine but no data are available about safety and efficacy of granulocyte-monocyte-apheresis (GMA) during pregnancy. In this case report, the 37 year-old pregnant woman with chronically active and steroid dependent ulcerative colitis (UC), at risk of abortion, refused more aggressive pharmacological therapeutic options and gave the informed consent to GMA. To minimize symptoms and the risk of severe clinical relapse, a maintenance GMA treatment was performed throughout pregnancy. The course of pregnancy was uneventful with no side effects; the mother and the baby were all healthy and well at the delivery. J. Clin. Apheresis, 2014. © 2014 Wiley Periodicals, Inc.


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