Literatür Detay Bilgisi
Fine-mapping of HLA associations with chronic lymphocytic leukemia in US populations.

Yazarlar : Gragert L, Fingerson S, Albrecht M et al

Yayın : Blood

Yayın Yılı : 2014

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/25232063

Konu : Lösemi

Literatür İçeriği :  Chronic Lymphocytic Leukemia (CLL) displays remarkable ethnic predisposition for Caucasians with relative sparing of African American and Asian populations. In addition, CLL displays among the highest familial predispositions of all hematologic malignancies, yet the genetic basis for these differences is not clearly defined. The highly polymorphic Human Leukocyte Antigen (HLA) genes of the Major Histocompatibility Complex (MHC) play a central role in immune surveillance and confer risk for autoimmune and infectious diseases and several different cancers, the role for which in the development of CLL has not been extensively investigated. The National Marrow Donor Program (NMDP) / Be The Match has collected HLA typing from CLL patients in need of allogeneic hematopoietic stem cell transplant (allo-SCT) and has recruited millions of volunteers to potentially donate hematopoietic stem cells. HLA genotypes for 3,491 US Caucasian, 397 African-American, and 90 Hispanic CLL patients were compared with 50,000 controls per population from the donor registry. We identified several HLA alleles associated with CLL susceptibility in each population, reconfirming predisposing roles of HLA-A*02:01 and HLA-DRB4*01:01 in Caucasians. Associations for haplotype DRB4*01:01~DRB1*07:01~DQB1*03:03 were replicated across all three populations. These findings provide a comprehensive assessment of the role of HLA in the development of severe CLL.


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