| Literatürler Hematoloji Uzmanlık Derneği
Literatür Detay Bilgisi
The impact of total body irradiation on the outcome of patients with follicular lymphoma treated with autologous stem cell transplantation in the modern era. A retrospective study of the ebmt lymphoma working party.

Yazarlar : El-Najjar I1, Boumendil A2, Luan JJ

Yayın : Ann Oncol

Yayın Yılı : 2014

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/25193988

Konu : Lenfoma

Literatür İçeriği :  

Abstract

BACKGROUND:

The aim of this study was to investigate the impact of the high-dose regimen on the outcome of patients with follicular lymphoma(FL) having had autologous stem cell transplantation (ASCT) in a recent time period.

PATIENTS:

Between 1995 and 2007, 2233 patients with FL had their first ASCT with either a total body irradiation-containing regimen (TBI) or BEAM, of which 47% were autografted in first remission.

RESULTS:

After a median observation time of 73 months (interquartile range 30-107), 5- and 10-year non-relapse mortality (NRM) was similar (6% and 10% in both groups). No significant NRM differences became evident after multivariate adjustment for confounders. Secondary malignancies were observed in 9.7% and 7.9% of the patients after TBI and BEAM (p=0.19), which were t-MDS/AML in 3.4% and 2.8% (p=0.57). The median time to t-MDS/AML was around 50 months in both groups. Because of a lower relapse incidence, TBI was associated with better event-free survival reaching statistical significance in the patients transplanted in first remission but not in those transplanted beyond first remission.

CONCLUSIONS:

In patients with FL who received TBI-based ASCT after 1995 increased NRM and t-MDS/AML risks did not emerge compared to BEAM whilst disease control was at least equivalent.


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