Literatür Detay Bilgisi
Cancer control and complications of salvage local therapy after failure of radiotherapy for prostate cancer: a systematic review

Yazarlar : Parekh A, Graham P, Nguyen P

Yayın : Semin Radiat Oncol

Yayın Yılı : 2014

Pubmed Linki :

Konu : Radyasyon Onkolojisi

Literatür İçeriği :  The National Comprehensive Cancer Network guidelines currently endorse salvage local therapy as a reasonable alternative to observation or androgen-deprivation therapy for select men with a biopsy-proven local recurrence after definitive radiation for prostate cancer. Patients being considered for salvage therapy should have had localized disease at presentation, a prostate-specific antigen<10 at recurrence, a life expectancy>10 years at recurrence, and a negative metastatic workup. In this systematic review, we synthesize the current literature describing the oncologic efficacy and toxicity profile of salvage brachytherapy, prostatectomy, cryotherapy, and high-intensity focused ultrasound. We found 5-year biochemical control rates to be similar across treatments, in the range of 52%-56%, although patient selection and definition of failure was variable. Toxicity profiles were also distinct between local salvage modalities.

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