Literatür Detay Bilgisi
Effects Of Blood Transfusion On Cytokine Profile and Pulmonary Function In Patients with Thalassemia Major;

Yazarlar : Gülhan B, Yalçın E, Unal S et al

Yayın : Clin Respir J

Yayın Yılı : 2014

Pubmed Linki :

Konu : Talasemi

Literatür İçeriği :  INTRODUCTION Thalassemia major (TM) is characterized by abnormal hemoglobin synthesis which results in decreased oxygen delivery to the tissues, ineffective erythropoiesis, and iron overload.

OBJECTIVES The purpose of this study was to find out the predominant type of lung mechanical abnormalities in TM patients, the prevalence of the change in pulmonary diffusing capacity and to search the association of cytokines with pulmonary function tests (PFTs).

METHODS Thalassemia major patients (n=26) who were on regular transfusion program were included in the study. Pretransfusional and posttransfusional PFTs were performed. Before transfusion, blood samples were collected for complete blood count, serum ferritin, zinc, transforming growth factor-β1 (TGF-β1), interleukin (IL)-8 and IL-10 levels.

RESULTS Obstructive lung pattern was the predominant pulmonary sequela. Male gender was the main risk factor for pulmonary function abnormality. Because of very low values, serum IL-10 levels of all patients were undetectable and serum IL-8 levels could be measured only in six patients. Median serum IL-8 level was higher in patients with abnormal PFT. Pretransfusional DLCO correlated negatively with serum TGF-β1 and ferritin levels. After transfusion, there was a statistically significant decrease in FEV1 , FEF25-75 and airway conductance but significant increase in DLCO. CONCLUSIONS: Although they are mostly asymptomatic, TM patients have important PFT abnormalities. Blood transfusion may have an acute deleterious effect on pulmonary functions. The disturbed pulmonary functions were found to correlate with IL-8 and TGF-β levels. Relations of different cytokines with different PFT parameters suggest that the immune system is effective pulmonary dysfunction.

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