Yazarlar : Ion D, Stevenson K, Woo S,

Yayın : Biol Blood Marrow Transplant

Yayın Yılı : 2014

Pubmed Linki : http://www.docguide.com/characterization-oral-involvement-acute-graft-versus-host-disease?tsid=5

Konu : Diğer

Literatür İçeriği :  BACKGROUND Acute graft-versus-host-disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (HSCT). The purpose of this study was to characterize the oral features associated with aGVHD.

METHODS Patients who underwent HSCT between 1995 and 2010 and developed prominent oral aGVHD. Data was collected from patient medical records and analyzed descriptively.

RESULTS Twenty-one cases were identified, of which 5 (24%) demonstrated only oral features; the remaining 16 had variable involvement of skin (n = 14), liver (n = 7), and gut (n = 5). The median time to onset of any sign of aGVHD was 22 days (range 8-154) whereas for oral aGVHD it was 35 days (range 11-159). Sites affected by non-specific erythema and ulcerations included buccal mucosa (19/21; 90%) tongue (18/21; 86%; dorsum in 8/21), labial mucosa (16/21; 76%), palatal mucosa (15/21; 71%; hard palate in 7/21), and floor of mouth (7/21; 33%); 8 cases (38%) presented with lip ulceration and crusting. In addition to systemic therapies, topical solutions of dexamethasone, tacrolimus, and morphine were utilized for ancillary support.

CONCLUSIONS Oral features of aGVHD may be the initial manifestation and include non-specific erythema and ulcerations of keratinized and non-keratinized mucosa and the lips. Intensive topical therapies may be helpful in reducing symptoms and promoting healing.

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