Literatür Detay Bilgisi
Analysis of factors associated with portal vein thrombosis in pediatric living donor liver transplant recipients

Yazarlar : Seda Neto J, Fonseca E, Feier F et al

Yayın : Liver Transpl

Yayın Yılı : 2014

Pubmed Linki :

Konu : Tromboz

Literatür İçeriği :  The technique of vascular reconstruction plays a major role in the outcome of living donor liver transplantation (LDLT). An increased use of vascular grafts (VG) to replace a sclerotic portal vein (PV) has become a standard technique in our group. The aim of this study is to analyze the factors associated with portal vein thrombosis (PVT) in pediatric LDLT. Retrospective analyses of 486 primary pediatric LDLT performed from Oct/1995 to May/2013. VG used for portal reconstruction included: living donor's inferior mesenteric vein (LDIMV) and ovarian vein (LDOV), recipient's internal jugular vein (RIJV), and deceased donor's iliac artery (DDIA) and vein (DDIV). A total of 34 (6.9%) patients developed PVT. The incidence of PVT dropped from 10% to 2%; overall utilization of VG increased from 3.5% to 37.1%. After multivariate analysis, only the use of VG remained as an independent risk factor for the occurrence of PVT (HR: 7.2, 95% CI: 2.8 to 18.7, P<0.0001). There was no difference in survival rates in patients with and without PVT. No patient with PVT was retransplanted. In conclusion, the use of VG was independently associated with the development of PVT. Over time there was a reduction in the incidence of early PVT in this cohort, and a trend towards reduction of total PVT. The occurrence of isolated PVT in this study was not associated with decreased patient or graft survival. Liver Transpl , 2014. © 2014 AASLD.

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