Literatür Detay Bilgisi
IKZF1 rs4132601 polymorphism and acute lymphoblastic leukemia susceptibility: a meta-analysis

Yazarlar : Li S, Ren L, Fan L, Wang G et al

Yayın : Leuk Lymphoma

Yayın Yılı : 2014

Pubmed Linki :

Konu : Lösemi

Literatür İçeriği :  Abstract Background: Several studies were conducted to examine the association between IKZF1 rs4132601 polymorphism and acute lymphoblastic leukemia (ALL) risk; however, the conclusions remained controversial. We therefore performed a meta-analysis. Material and Method: PubMed, Embase, Web of Science, Weipu, and CBM databases were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Results: A total of 15 case-control studies with 8333 cases and 36036 controls were included in this meta-analysis. The result suggested that rs4132601 was associated with an increased ALL risk. Significant associations were found among Caucasians and Hispanics but not among Asians. In the subgroup analysis by age group, both adults and children showed increased ALL risks, respectively. In the subgroup analysis by subtype of ALL, significantly increased risks were observed in B-cell ALL, B hyperdiploid ALL, but not in T-cell ALL. Conclusions: This study suggested that IKZF1 rs4132601polymorphism was a risk factor for ALL.

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