Literatür Detay Bilgisi
Bortezomib and dexamethasone for multiple myeloma: higher AST and LDH levels associated with a worse prognosis on overall survival;

Yazarlar : Kiba T, Ito T, Nakashima T, Okikawa Y et al

Yayın : BMC Cancer

Yayın Yılı : 2014

Pubmed Linki :

Konu : Myelom

Literatür İçeriği :

BACKGROUND Bortezomib offers a novel approach to the treatment of multiple myeloma producing rapid control. The aim of this study was to investigate the outcomes of bortezomib and dexamethasone-treated patients with multiple myeloma.

METHODS We conducted a retrospective study of 44 consecutively-treated multiple myeloma patients with bortezomib (1.3 mg/m2 on days 1, 4, 8, and 11 of a 21-day cycle or 1.3 mg/m2 intravenously 1, 8, 15, and 22 of every 35-day cycle) and dexamethasone.

RESULTS The median time to progression, progression free survival time, and overall survival time in the treatment groups was 14.9, 14.9, and 38.3 months, respectively. The present study also suggests the possibility that the prognosis of patients with high levels of AST and LDH might be worse.

CONCLUSIONS Our results indicate that the treatment of multiple myeloma with bortezomib and dexamethasone is feasible.

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