Yazarlar : Leuk Lymphoma

Yayın : Ferrà C, Sanz J, Díaz-Pérez M et al

Yayın Yılı : 2014

Pubmed Linki : http://www.docguide.com/outcome-graft-failure-after-allogeneic-stem-cell-transplantation-study-89-patients?tsid=5

Konu : Kemik İliği Nakli

Literatür İçeriği :  ABSTRACT Strategies for reversing graft-failure (GF) after allogeneic stem cell transplant (SCT) depend on the options available in each situation. GF was reported in 16 Spanish institutions from January 2006 to July 2011. Primary GF was defined as ANC>0.5x10(9)/L not reached by day +28 after SCT from peripheral blood (PB) or bone marrow (BM) progenitors and by day +42 after SCT from unrelated cord blood (UCB) progenitors. Secondary GF was defined as a recurrent ANC<0.5x10(9)/L. Eighty-nine patients with GF were reported, and 80 patients received a second SCT. The 5-yr. survival probability was 31% (95%CI: 18%-44%), and the incidences of non-relapse mortality and relapse estimated by competing risks were 47% [95%CI: 36%-58%] and 21% [95%CI: 4%-28%]. The strategy adopted to treat GF was heterogeneous and no approach could be unequivocally recommended for this situation. The prognosis of patients with GF was poor even after successful recovery from GF.

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