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Advances in Umbilical Cord Blood Transplantation- A Summary of the 11(th) International Cord Blood Symposium San Francisco June 6(th)-8(th) 2013

Yazarlar : van Besien K; Leukemia and Lymphoma

Yayın : Leuk Lymphoma

Yayın Yılı : 2014

Pubmed Linki :

Konu : Rejeneratif Tıp

Literatür İçeriği :  Abstract The 11th international Cord Blood Meeting was devoted to advances in umbilical cord blood research and transplantation. Results of cord blood transplant (UCB-SCT) for congenital storage disease and hemoglobinopathies are encouraging, but UCB-SCT may also be useful for older adults with hematologic malignancies and UCB have potential in regenerative medicine, particularly for neurological disorders and may serve as excellent targets for gene therapy. UCB donor selection should consider high resolution HLA typing, maternal HLA typing and detection of donor specific HLA-antibodies. The issue of delayed hematopoietic reconstitution has hamstrung UCB SCT but is addressed to a large extent by co-infusion of third party progenitor cells. A number of cell expansion technologies also have great potential. Novel data show more limited benefits of double vs single umbilical cord blood transplantation. Advances in QC of UCB products and other improvements in cord blood banking technology will further improve the quality of stored UCB products.

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