Literatür Detay Bilgisi
Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4
Yazarlar : Ramos P, Karnezis A, Craig D et al
Yayın : Lung Cancer
Yayın Yılı : 2014
Pubmed Linki : http://www.docguide.com/small-cell-carcinoma-ovary-hypercalcemic-type-displays-frequent-inactivating-germline-and-somatic-mu?tsid=5
Konu : Tıbbi Onkoloji
Literatür İçeriği : Small cell carcinoma of the ovary of hypercalcemic type (SCCOHT) is an extremely rare, aggressive cancer affecting children and young women. We identified germline and somatic inactivating mutations in the SWI/SNF chromatin-remodeling gene SMARCA4 in 75% (9/12) of SCCOHT cases in addition to SMARCA4 protein loss in 82% (14/17) of SCCOHT tumors but in only 0.4% (2/485) of other primary ovarian tumors. These data implicate SMARCA4 in SCCOHT oncogenesis.
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