Yazarlar : Shankar A, Hayward J, Kirkwood A et al

Yayın : Br J Haematol

Yayın Yılı : 2014

Pubmed Linki : http://www.docguide.com/treatment-outcome-children-and-adolescents-relapsed-hodgkin-lymphoma-results-uk-hd3-relapse-treatmen?tsid=5

Konu : Diğer

Literatür İçeriği : The purpose of this national retrospective study was to evaluate the outcome in children with relapsed or primary refractory Hodgkin lymphoma [HL] after a primary chemotherapy alone treatment strategy. Between 2000 and 2005, 80 children with relapsed [n = 69]or primary refractory [n = 11] HL were treated on a standardized treatment protocol of 4-6 cycles of EPIC [etoposide, prednisolone, ifosfa3mide and cisplatin]chemotherapy. Radiotherapy was recommended to all relapsed sites. High dose therapy with stem cell rescue [SCT] was recommended for patients with poor response. The 5-year overall survival [OS]and progression-free survival from relapse was 75·8% [64·8-83·9] and 59·9% [48·3-69·7]respectively. Duration of first remission was strongly associated with OS; risk of death was decreased by 53% [Hazard ratio (HR): 0·47, 95% confidence interval (CI): 0·19-1·18] for those with a time from end of treatment to relapse of 3-12 months (compared to<3 months) and reduced by 80% (HR 0·20, 95% CI: 0·04-0·90) for those>12 months after end of treatment. Other poor prognostic factors included advanced stage disease at relapse and B symptoms at first diagnosis. The most important factor associated with salvage failure was time to relapse. Survival outcome in children with primary refractory HL is poor.

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