Literatür Detay Bilgisi
Assessment of clonality in T-cell large granular lymphocytic leukemia: flow cytometric T cell receptor Vβ repertoire and T cell receptor gene rearrangement;

Yazarlar : Qiu Z, Wen-Yi S, Fan L et al

Yayın : Leuk Lymphoma

Yayın Yılı : 2014

Pubmed Linki : http://www.docguide.com/assessment-clonality-t-cell-large-granular-lymphocytic-leukemia-flow-cytometric-t-cell-receptor-v-re?tsid=5

Konu : Anemi

Literatür İçeriği :  Abstract The usefulness of flow cytometric variable β-chain repertoire (FC-Vβ) and T-cell receptor gene rearrangement (TCR-GR) analyses for differentiating T-cell large granular lymphocytic leukemia (T-LGLL) from reactive T-LGL lymphocytosis has been insufficiently studied to date. In this study, we analyzed the diagnostic value of TCR-GR and FC-Vβ analysis in T-LGLL, and compared these results. In our study, FC-Vβ analysis was positive in all T-LGLL cases, and clonality assessment of FC-Vβ had equal sensitivity and specificity to GeneScanning analysis but more sensitive than heteroduplex analysis. Suspected T-cell clonality can best be addressed by evaluating two TCR targets (TCRβ and TCRγ), either in parallel or consecutively. STAT3 mutation may provide a diagnostic tool for classifying some cases of T-LGL lymphocytosis as true T-LGLL. Our results further demonstrate the remarkable correlation of STAT3 mutation with PRCA, neutropenia, hepatomegaly, β2-MG and anemia.


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