Yazarlar : Yabe M, Morimoto T, Shimizu T et al

Yayın : Bone Marrow Transplant

Yayın Yılı : 2014

Pubmed Linki : http://www.docguide.com/feasibility-marrow-harvesting-pediatric-sibling-donors-without-hematopoietic-growth-factors-and-allo?tsid=5

Konu : Kemik İliği Nakli

Literatür İçeriği :  We retrospectively studied 108 marrow harvests from 105 pediatric sibling donors. The median age of donors was 8 years (range: 1-15) and the median body weight was 27 kg (range: 10-100). The volumes of aspirated marrow were 5.0-23.8 mL/kg donor body weight, and harvested bone marrow volume exceeded 15 mL/kg in 42% of the donors. A total of 100 autologous blood donations were performed, and eight donors had red cells salvaged from their harvests reinfused. The median Hb levels before and after harvests were 12.3 g/dL (range: 10.0-14.7) and 11.0 g/dL (range: 8.9-13.8), respectively. None of the donors received allogeneic blood transfusions or hematopoietic growth factors such as EPO and G-CSF before or after collection. Transplanted dose was 1.4-10.8 × 10(8) cells/kg recipient body weight without differences due to donor age. Higher concentrations of nucleated and CD34(+) cells were obtained from younger donors. All donors tolerated the procedures well, with no serious complications. Thus, children may safely donate marrow for allogeneic transplantation, and the yields of nucleated cells for engraftment are substantial.Bone Marrow Transplantation advance online publication, 28 April 2014; doi:10.1038/bmt.2014.73.

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