Yazarlar : Mollee P.

Yayın : Pathology.

Yayın Yılı : 2014

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/24557252

Konu : Myelom

Literatür İçeriği : Amyloidosis is a rare but devastating condition caused by deposition of misfolded proteins as aggregates in the extracellular tissues of the body, leading to impairment of organ function. Correct identification of the causal amyloid protein is absolutely crucial for clinical management in order to avoid misdiagnosis and inappropriate, potentially harmful treatment, to assess prognosis and to offer genetic counselling if relevant. This review summarises the current evidence on which the diagnosis and subtyping of amyloidosis is based, outlines the limitations of various diagnostic techniques, particularly in an Australian and New Zealand context, and discusses optimal strategies for the diagnostic approach to these patients.After decades of little progress in the last century, multiple myeloma survival has improved significantly in the last 15 years. This improvement has been built on better understanding of disease biology and pathogenesis which has led to a requirement to thoroughly evaluate patients and their disease. While serum and urine protein electrophoresis and the skeletal survey remain cornerstones of myeloma assessment, newer techniques including serum free light chain assays, bone marrow flow cytometry, cytogenetics and genomic analysis, as well as newer bone imaging modalities have moved into standard practice. Recent consensus statements outlining the approach to diagnosis and monitoring of myeloma will be reviewed.

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