Literatür Detay Bilgisi
Innovations: advances in cellular therapies relating to haematological conditions.

Yazarlar : Rasko J.

Yayın : Pathology.

Yayın Yılı : 2014

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/24557248

Konu : Rejeneratif Tıp

Literatür İçeriği : It is an exciting time for genetic and cellular therapies. Since 1989 over 1500 Phase I/II studies of direct in vivo and cell-mediated gene therapy in diverse diseases have been completed. Substantial evidence of improved clinical outcomes has been shown in haemophilia B, immune deficiencies, haemoglobinopathies, immunotherapies and blindness. In the field of cellular therapeutics, applications have expanded beyond the foundation in autologous and allogeneic haemopoietic cell transplantation to mesenchymal and other adult cell therapy trials. Indeed, if pluripotent cells can be differentiated ex vivo to recreate and repair mature human tissues and organs, then regenerative medicine will become a reality. However embryonic stem cells have been mired in controversy and clinical development has been forestalled. Medical and, in particular, stem cell tourism has become a billion dollar industry with increasing examples of false claims. Unregulated, untested or unsafe stem cell 'therapies' place the field at a challenging crossroad.


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