Yazarlar : Kekre N, Chou A, Tokessey M, Doucette S, Tinmouth A, Tay J, Allan DS.
Yayın : Transfusion.
Yayın Yılı : 2011
Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/21569047
Konu : Transfüzyon
Literatür İçeriği :
Abstract
BACKGROUND:
Red blood cell (RBC) transfusion may prolong recovery in some patients, perhaps due to changes that occur during more prolonged RBC storage. We examined the impact of RBC transfusion and the age of transfused RBC units on clinical outcomes in hematopoietic stem cell transplantation (HSCT).
STUDY DESIGN AND METHODS:
Data concerning RBC transfusions between Day 0 and Day +30 were analyzed for patients undergoing HSCT (n = 555) at a single institution. "Old" RBC units were defined as those stored for 15 days or longer.
RESULTS:
The proportion of old RBC units transfused and the mean age of transfused units did not correlate with 100-day nonrelapse mortality, organ-specific toxicity, length of stay (LOS), or incidence of intensive care unit (ICU) admission (p > 0.05). In comparing the 71 patients who received only old RBC units with 218 patients who received only "new" RBC units, there was no increase in adverse clinical outcomes after HSCT. Autologous transplant recipients (n = 355, 3.8 units/patient) were more likely to avoid RBC transfusion and received fewer units compared with allogeneic recipients (n = 200, 6.4 units/patient, p < 0.0001). The mean number of transfused RBC units was greater in patients admitted to the ICU (10.5 units vs. 3.7 units/patient, p < 0.01), correlated with longer LOS (p < 0.0001), and correlated with increasing number of organ systems with toxicity of at least Grade 2 (p < 0.0001).
CONCLUSION:
The importance of RBC storage time does not appear to influence clinical outcomes in HSCT. Patients with increased RBC transfusion requirements have greater toxicity after HSCT. Whether RBC transfusion contributes to toxicity, however, remains unclear.| Sunumlar | Videolar | Olgu Tartışması |
