Yazarlar : Vassilopoulou S, Anagnostou E, Paraskevas G, Spengos K.
Yayın : Eur J Neurol.
Yayın Yılı : 2011
Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/21631645
Konu : Talasemi
Literatür İçeriği :
Abstract
Background and purpose: Although hypercoagulability-induced thromboembolism is generally accepted as cause of cerebral ischaemia in thalassemic patients, cardiogenic embolism has been recently suggested as another possible stroke etiology. Methods: We present four adult β-thalassemia major patients with manifest cardiac involvement who suffered territorial strokes. Results: In the presence of siderotoxic cardiomyopathy and arrhythmia, we assumed cardiogenic embolism as etiology of stroke and initiated oral anticoagulation as preventive medication. Two of our patients were the first β-thalassemia major patients who underwent successful thrombolysis with rtPA. Conclusions: Cardioembolism seems to be the cause of stroke in cases of β-thalassemia major. Thrombolysis can be applied in the setting of acute brain ischaemia in such high risk patients.
© 2011 The Author(s). European Journal of Neurology © 2011 EFNS.
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