Literatür Detay Bilgisi
Idiopathic aplastic anemia: Diagnosis and Classification.

Yazarlar : Dolberg OJ1, Levy Y2.

Yayın : Autoimmun Rev.

Yayın Yılı : 2014

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/24424170

Konu : Anemi

Literatür İçeriği :  

Abstract

Aplastic anemia (AA) is a disease characterized by pancytopenia and hypoplastic bone marrow caused by the decrease of hematopoietic stem cells. The pathogenesis of AA is complex and involves an abnormal hematopoietic microenvironment, hematopoietic stem cell/progenitor cell deficiencies and immunity disorders. Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive biologics and drugs, and supportive care. Herein, we will update the main issues concern AA according to our literature review.


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