Multiple myeloma is a heterogeneous hematologic disorder of plasma cells with varied bone marrow imaging appearances. With advancements in both treatment and use of advanced imaging over the last several decades, it is important for radiologists to recognize the imaging presentation of the disease and the staging implications of imaging. This paper reviews the staging as it relates to imaging, consensus recommendations for imaging, expected imaging appearances of myeloma, pitfalls, and complications associated with treatment that are demonstrable on imaging.