Yazarlar : El-Galaly TC, Hutchings M, Mylam KJ, et al

Yayın : Leuk Lymphoma.

Yayın Yılı : 2013

Pubmed Linki : http://www.ncbi.nlm.nih.gov/m/pubmed/24354682/

Konu : Radyasyon Onkolojisi

Literatür İçeriği :  

Abstract

ABSTRACT 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) is a highly accurate staging method in classical Hodgkin lymphoma (cHL). We retrospectively compared the staging results obtained in two large cohorts of cHL patients diagnosed before (N=324) and after (N=406) the introduction of PET/CT staging in a retrospective study. In the PET/CT-staged patients, stage I disease was less frequent (16% vs. 27%, P <0.001), while stage IV disease was more frequent (17% vs. 10%, P =0.02). Imaging-detected skeletal involvement was recognized more often in PET/CT staged patients (17% vs. 2%, P <0.001) and the presence of focal skeletal PET/CT lesions was associated with higher risk of progression (Hazard ratio 1.96, 95% CI: 1.14-3.36). The GHSG risk classification (early, intermediate, advanced disease) predicted outcome in PET/CT staged patients. In conclusion, PET/CT has led to higher disease stages and the more frequently diagnosed skeletal lesions may be an adverse prognostic factor.

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