Yazarlar : Akyol G, Pala C, Yildirim A, et al

Yayın : Transfus Apher Sci.

Yayın Yılı : 2013

Pubmed Linki : http://www.ncbi.nlm.nih.gov/m/pubmed/24360843/

Konu : Anemi

Literatür İçeriği :  

Abstract

BACKGROUND: Granulocyte-colony stimulating factor (G-CSF) is widely administered to donors who provide peripheral blood stem cells (PBSCs) for individuals who undergo hematopoietic stem cell transplants. G-CSF administration is associated with a small but definite risks of serious adverse events like splenic rupture.

CASE STUDY: In this case, we report a 40year old women, a healthy donor for her sister who has aplastic anemia, who had sharp left upper abdominal pain on the forth mobilization day. The diagnosis at CT scan was splenic rupture; irregular intrasplenic low-attenuation areas consistent with ruptured spleen and perisplenic high density fluid. Her bidimensional spleen size was 16×6cm.

RESULTS: She was followed conservatively. One month later the CT scan signs of rupture disappeared.

CONCLUSION: We must pay attention to this rare but serious adverse event during filgrastim use.

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