Yazarlar : Spiezia L, Campello E, Bon M, Tison T, Milan M, Simioni P, Prandoni P.

Yayın : Blood Transfus.

Yayın Yılı : 2012

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/23114529

Konu : Tromboz

Literatür İçeriği :

BACKGROUND:
Although having a non-O blood type is now regarded as a risk factor for venous thromboembolism, the strength of this association is poorly defined, as is its interaction with inherited thrombophilia.

MATERIALS AND METHODS:
The prevalence of non-O blood group and inherited thrombophilia (deficiencies of natural anticoagulants, factor V Leiden and prothrombin G20210A mutation) was assessed in a series of 712 consecutive patients with proximal deep vein thrombosis (DVT) of the lower limbs who were referred to our Institution between 2004 and 2010, and in 712 age- and gender-matched healthy volunteers. Odds ratios (OR) of DVT and their 95% confidence intervals (CI) were computed for non-O group and thrombophilia, both separately and in combination.

RESULTS:
A non-O blood group was present in 492 cases and 358 controls (OR 2.21; 95% CI, 1.78 to 2.75). A thrombophilic abnormality was present in 237 cases and 105 controls (OR 2.82; 2.18 to 3.66). The combination of non-O group and thrombophilia was present in 152 cases and 51 controls (OR 7.06; 4.85 to 10.28).

DISCUSSION:
Having a non-O blood group is associated with an increased risk of proximal DVT of the lower limbs with or without pulmonary embolism. The addition of inherited thrombophilia increases the thrombotic risk conferred by non-O group alone by almost 3-fold.

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