Yazarlar : Solji V, Perak RB, Vukojevi K, Saraga-Babi M, Bubalo P, Karan D, Todorovi J, Batini D.

Yayın : Leuk Lymphoma

Yayın Yılı : 2012

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/23098292

Konu : Lösemi

Literatür İçeriği : Abstract The expression of 70-kDa protein zeta-associated protein (ZAP-70) in chronic lymphocytic leukemia (CLL) was used to detect those patients with more aggressive disease. The aim of this study was to determine proliferative activity of ZAP-70(+) leukemic cells by immunocytochemical methods. The study was undertaken on native blood marrow (BM) and peripheral blood (PB) smears from 65 CLL patients. ZAP-70 was expressed in leukemic cells of 35 patients (54%). We demonstrated that ZAP-70 immunoreactivity correlated with Rai 0-IV (p=0.002) and Binet A-C stage (p<0.001), total tumor mass (TTM-score) (p<0.001), β(2)-mikroglobulin (p=0.006), atypical lymphocytes (p<0.001), and proliferative activity in bone marrow and peripheral blood (p=0.014; p=0.002 respectively) using χ(2) test and Mann-Whitney test. ZAP-70 protein expression is in direct correlation with the poorer prognostic parameters, which additionally confirms the successful detection method of ZAP-70 expression. Higher Ki-67 expression in BM and PB smears of ZAP-70(+) patients indicates higher proliferating compartments, which may be contributed to poorer prognosis of the disease.

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