Yazarlar : Institute for Quality and Efficiency in Health Care: Executive Summaries [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG)

Yayın : Quality and Efficiency in Health Care (IQWiG)

Yayın Yılı : 2005

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/23101063

Konu : Lenfoma

Literatür İçeriği : This investigation had 2 aims 1. Determining the patient-relevant benefit of PET and/or PET/CT. This was primarily concerned with describing the patient-relevant benefit that doctors and patients can expect from imaging procedures using PET or PET/CT in malignant lymphoma. Its use was considered in the following indications: a. Determination of the tumour stage (staging), b. Treatment response of lymphoma (residual disease evaluation/restaging), and c. Evidence of recurrence in the case of justified suspicion.. “Benefit” was understood here to mean changes that have perceptible consequences for the patient, such as the effect on mortality and morbidity, the optimum choice of treatment options available with more or less toxic side effects, the general clinical management of the patient and changes in quality of life. 2. Assessing the diagnostic and prognostic accuracy of PET or PET/CT. Due to the lack of valid primary trials on determining patient-relevant benefit (first aim), a systematic assessment of the diagnostic and prognostic accuracy of PET or PET/CT was also carried out (second aim). This was primarily concerned with finding out to what extent PET or PET/CT is superior to the standard diagnostic procedure without PET. In other words: Does the use of PET or PET/CT offer an improvement in accurate staging along with the various prognostic consequences, in the accurate recognition of patients with or without residual tumours after treatment is finished, or in the correct diagnosis or correct exclusion of recurrences? In a similar vein, does the use of PET or PET/CT enable more reliable prognostic statements to be made concerning a recurrence than was possible with existing standard diagnostic procedures?

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