| Literatürler Hematoloji Uzmanlık Derneği
Literatür Detay Bilgisi
Response to Low-dose Bortezomib in Plasma Cell Leukemia Patients with Malignant Pleural Effusion and Ascites: A Case Report and a Review of the Literature.

Yazarlar : Sekiguchi Y, Shirane S, Imai H, et al

Yayın : Intern Med.

Yayın Yılı : 2012

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/22687849

Konu : Myelom

Literatür İçeriği :

Pleural effusion or ascites complicating plasmacytoma is rare and has a poor prognosis. A 70-year-old man was diagnosed as plasma cell leukemia and one course of ranimustine-vindesine, melphalan, and prednisolone followed by melphalan and prednisone (MP) maintained a very good partial response. After MP he was diagnosed to have pleural effusion and ascites as a complication of the plasmacytoma. Low-dose bortezomib caused disappearance of the malignant effusion. The malignant effusions recurred after the end of the second course of bortezomib. High-dose dexamethasone vincristine, doxorubicin, cyclophosphamide, and prednisone yielded no benefit, the patient died of Aspergillus pneumonia.


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