Yazarlar : Hole PS, Darley RL, Tonks A.

Yayın : Blood

Yayın Yılı : 2011

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/21398578

Konu : Lösemi

Literatür İçeriği :  

Abstract

Reactive oxygen species (ROS) are a heterogeneous group of molecules that are generated by mature myeloid cells during innate immune responses, and are also implicated in normal intracellular signalling. Excessive production of ROS (and/or a deficiency in antioxidant pathways) can lead to oxidative stress, a state which has been observed in several haematopoietic malignancies including acute and chronic myeloid leukaemias (AML and CML). Currently it is unclear what the cause of oxidative stress might be and whether oxidative stress contributes to the development, progression or maintenance of these diseases. This article reviews the current evidence suggesting a role for ROS both in normal haematopoiesis and in myeloid leukaemogenesis, and discusses the usefulness of therapeutically targeting oxidative stress in myeloid malignancy.

Literatür Arşivi