Yazarlar : McNamara LE, Sjöström T, Meek RM, Oreffo RO, Su B, Dalby MJ, Burgess KE.
Yayın : J R Soc Interface.
Yayın Yılı : 2012
Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/22628210
Konu : Rejeneratif Tıp
Literatür İçeriği :
Abstract
Metabolomics is a method for investigation of changes in the global metabolite profile of cells. This paper discusses the technical application of the approach, considering metabolite extraction, separation, mass spectrometry and data interpretation. A particular focus is on the application of metabolomics to the study of stem cell physiology in the context of biomaterials and regenerative medicine. Case studies are used to illustrate key points, focusing on the use of metabolomics in the examination of mesenchymal stem cell responses to titania-nanopillared substrata designed for orthopaedic applications.
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