| Literatürler Hematoloji Uzmanlık Derneği
Literatür Detay Bilgisi
Breast cancer stem cells: obstacles to therapy.

Yazarlar : Smalley M, Piggott L, Clarkson R.

Yayın : Cancer Lett.

Yayın Yılı : 2012

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/22554712

Konu : Rejeneratif Tıp

Literatür İçeriği :  

Abstract

Only a fraction of the cells in a breast tumour are able to seed new tumour growth. These so-called breast cancer stem cells (bCSCs) are characterized by a number of discrete functional properties, some of which impact on therapeutic strategies aimed at eliminating these cells from tumours. Here we discuss how recent experimental evidence indicates that phenotypic plasticity is a central feature of tumour cell heterogeneity and drug resistance, traits that must be overcome in order to efficiently target bCSCs as a therapy for breast cancer. We propose that a better understanding of this fundamental property of breast cancer stem cells, over and above their identification in tumours, is a priority for improvement of patient survival.


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