Yazarlar : Kristinsson SY, Pfeiffer RM, Bjorkholm M, Schulman S, Landgren O.

Yayın : Haematologica.

Yayın Yılı : 2012

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/22511493

Konu : Tromboz

Literatür İçeriği :  

Abstract

Patients with multiple myeloma are at an increased risk of venous thromboembolism and arterial thrombosis. We assessed the impact of venous and arterial thrombosis on survival in a population-based study on 9,399 multiple myeloma patients diagnosed in Sweden 1987-2005. We found multiple myeloma patients with (versus without) venous thromboembolism to have a higher mortality at 1-, 5-, and 10-years of follow-up, with hazards ratio=2.9 (95% confidence interval 2.4-3.5), 1.6 (1.5-1.8), and 1.6 (1.4-1.7), respectively. The risk of dying was increased among multiple myeloma patients with arterial thrombosis, hazard ratio=3.4 (3.0-3.8), 2.2 (2.0-2.3), and 2.1 (1.9-2.1), respectively. In landmark analyses at 6 months, early arterial and notvenous thromboembolism was associated with a higher risk of dying. Thus, in contrast to prior smaller studies, we found the development ofthrombosis to be associated with significantly poorer survival. The prevention of thrombosis in multiple myeloma is an important goal in the management of multiple myeloma patients.

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