Literatür Detay Bilgisi
Familial monoclonal gammopathy of undetermined significance and multiple myeloma: epidemiology, risk factors, and biological characteristics.
Yazarlar : Greenberg AJ, Rajkumar SV, Vachon CM.
Yayın : Blood
Yayın Yılı : 2012
Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/22354002
Konu : Myelom
Literatür İçeriği :
Abstract
Monoclonal gammopathy of undetermined significance (MGUS), a precursor to multiple myeloma, is one of the most common premalignant conditions in the general population. The etiology of MGUS is largely unknown. Recent studies show that there is an increased prevalence of MGUS in blood relatives of individuals with lymphoproliferative and plasma cell proliferative disorders, suggesting presence of shared underlying genetic influences. In the past few years, additional studies have examined risk factors and biological characteristics that may contribute to the increased prevalence of MGUS among relatives of probands with MGUS, multiple myeloma (MM), and other blood malignancies. This manuscript reviews the known epidemiology and risk factors of familial MGUS and myeloma, the risk of lymphoproliferative disorders and other malignancies among blood-relatives of patients with MGUS and MM, and discusses future directions for researchKonusu Aynı Olan Diğer Materyaller
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