Yazarlar : Chueamuangphan N, Wongtheptien W, Nawarawong W et al
Yayın : J Med Assoc Thai.
Yayın Yılı : 2012
Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/22379736
Konu : Talasemi
Literatür İçeriği :
Abstract
OBJECTIVE:
To explore clinical indicators for pulmonary arterial hypertension (PAH) in thalassemia (Thal).
MATERIAL AND METHOD:
A study was conducted in thalassemia patients at Chiang Rai Hospital, Chiang Rai, Thailand. Pulmonary artery systolic pressure (PASP) was determined by doppler echocardiography and PAH was defined as PASP > 35 mmHg. Patient characteristics were extracted from medical records. Characteristics of patients with and without PAH were compared. Risk indicators were explored with logistic regression analysis.
RESULTS:
Two hundred twenty four patients were included, 144 E/beta-Thal, 37 homozygous beta-Thal and 43 Hb H disease. There were 65 patients (29.0%) with PAH, 53 (81.5%) with E/beta-Thal, 8 (12.3%) with homozygous beta-Thal and 4 (6.2%) with Hb H disease. In a multivariable analysis, features significantly associated with PAH were E/beta-Thal (OR = 1.98, 95% CI; 1.29-3.01) and post splenectomy status (OR = 2.36, 95% CI; 1.17-4.73).
CONCLUSION:
Significant indicators for PAH in thalassemia were E/beta-Thal and post splenectomy status.
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