Yazarlar : Fozza C, Longinotti M.

Yayın : Eur J Haematol.

Yayın Yılı : 2012

Pubmed Linki : http://www.ncbi.nlm.nih.gov/pubmed/22296182

Konu : MDS

Literatür İçeriği :  

Abstract

Even though the pathogenesis of myelodysplastic syndromes (MDS) is dominated by an inefficient maturation of hematopoietic precursors, also immune mechanisms seem to play a crucial functional role. In this review we will first describe the clinical and laboratory autoimmune manifestations often detectable in MDS patients. We will then focus on studies addressing the mechanisms of T-cell activation and their implications in the disease history. The potential impact of specific cell subsets, such as regulatory T-cells, Th17 cells and natural killer cells, will be also described. We will finally focus on potential therapeutic approaches based on immunomodulation, ranging from more classical immunosuppressive drugs to vaccination and transplantation strategies. © 2012 John Wiley & Sons A/S

Literatür Arşivi